위암에서 Mac - 2 항원 발현에 관한 연구

• Published in: The Korean journal of gastroenterology Vol. 32; no. 1; pp. 38 - 44
• Main Authors: 김진복, Jin Pok Kim, 김우호, Woo Ho Kim, 김용일, Yong Il Kim, 양한광, Han Kwang Yang, 이원애, Wan Ae Lee
• Format: Journal Article
• Language: Korean
• Published: 대한소화기학회 20-11-1998
• Subjects: Desmoplasia; Gastric carcinoma; Mac-2
• ISSN: 1598-9992

Background/Aims: Mac-2 antigen is a phosphoprotein involved in cell adhesion and cell division. It is also known to be up-regulated by transfection of oncogenes. Methods: To investigate the clinical significance of Mac-2 antigen in gastric careinoma, we analyzed 92 cases of Korean patients with gastric cancer in the aspect of the Mac-2 antigen expression and its relation with clinicopathological parameters. Results: The Mac-2 antigen was not expressed in normal gastric mucosa, but was positive focally in the epithelium with intestinal metaplasia. Increased expression was observed in 52 cases of gastric carcinoma (56.5%) out of 92 cases. The increased expression of Mac-2 in the tumor was positively correlated with stromal collagen production. The Mac-2 expression was not correlated with histologic type, depth of invasion, inflammatory reaction, lymph node metastasis, or clinical stage. Conclusions: The Mac-2 expression is positively correlated with desmoplastic reaction of the gastric carcinoma tissue. Further study will be needed to elucidate the mechanism. (Kor J Gastroenterol 1998;32:38 - 44)