Autophagy To Survive

Autophagy is the catabolic mechanism that involves cell degradation of unnecessary or dysfunctional cellular components through the actions of lysosomes. It helps to keep the cells alive in such cases like oxidative stress, lack of nutrients and growth factors providing recycling of intracellular mo...

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Bibliographic Details
Published in:	Arşiv Kaynak Tarama Dergisi Vol. 23; no. 3
Main Authors:	İzmirli,Müzeyyen, Ecevit,Hasret, Gögebakan,Bülent
Format:	Journal Article
Language:	English
Published:	Çukurova Üniversitesi Tıp Fakültesi 01-03-2014
Subjects:	Sağlık Hizmetleri Tıp Adana Türkiye Chaperone-mediated autophagy Mikrootofaji Makrootofaji Şaperon Aracılı Otofaji Macro-autophagy Micro-autophagy Autophagy Otofaji
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Summary:	Autophagy is the catabolic mechanism that involves cell degradation of unnecessary or dysfunctional cellular components through the actions of lysosomes. It helps to keep the cells alive in such cases like oxidative stress, lack of nutrients and growth factors providing recycling of intracellular molecules. However, it works as a part of metabolism regulation, morphogenesis, cell differentiation, senescence, cell death and immune system. There are three subtype including macro-autophagy, micro- autophagy, chaperone-mediated autophagy. As a result of impairment of this mechanism, pathological situations arise including cancer, neurodegenerative and infectious diseases. Consequently, researches about autophagy mechanism are important for the development of novel diagnosis, follow-up and treatment modalities in health problems. For the first time, the review purposes to provide three subtypes of autophagy to reader.