EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2

Highlights d EXD2 is required for cell survival in response to replicative stress d EXD2 protects replication forks from over resection by counteracting fork reversal d EXD2 is synthetic lethal with the deficiency in BRCA1/2 genes Authors

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Bibliographic Details
Published in:Molecular cell Vol. 75; pp. 605 - 619
Main Authors: Nieminuszczy, Jadwiga, Broderick, Ronan, Bellani, Marina A, Smethurst, Elizabeth, Schwab, Rebekka A, Cherdyntseva, Veronica, Evmorfopoulou, Theodora, Lin, Yea-Lih, Minczuk, Michal, Pasero, Philippe, Gagos, Sarantis, Seidman, Michael M, Niedzwiedz, Wojciech
Format: Journal Article
Language:English
Published: Cell Press 08-08-2019
Subjects:
Life Sciences
Online Access:Get full text
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Summary:Highlights d EXD2 is required for cell survival in response to replicative stress d EXD2 protects replication forks from over resection by counteracting fork reversal d EXD2 is synthetic lethal with the deficiency in BRCA1/2 genes Authors
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2019.05.026