IN/I-Arylation of 3-Formylquinolin-2-Catalyzed Chan–Lam Coupling

IN/I-Arylation of 3-Formylquinolin-2-Catalyzed Chan–Lam Coupling

3-formyl-2-quinolones have attracted the scientific community's attention because they are used as versatile building blocks in the synthesis of more complex compounds showing different and attractive biological activities. Using copper-catalyzed Chan-Lam coupling, we synthesized 32 new N-aryl-...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Vol. 27; no. 23
Main Authors: Valencia, Jhesua, Sánchez-Velasco, Oriel A, Saavedra-Olavarría, Jorge, Hermosilla-Ibáñez, Patricio, Pérez, Edwin G, Insuasty, Daniel
Format: Journal Article
Language:English
Published: MDPI AG 01-11-2022
Subjects:
Copper
Copper compounds
Heterocyclic compounds
Online Access:Get full text
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Summary:3-formyl-2-quinolones have attracted the scientific community's attention because they are used as versatile building blocks in the synthesis of more complex compounds showing different and attractive biological activities. Using copper-catalyzed Chan-Lam coupling, we synthesized 32 new N-aryl-3-formyl-2-quinolone derivatives at 80 °C, in air and using inexpensive phenylboronic acids as arylating agents. 3-formyl-2-quinolones and substituted 3-formyl-2-quinolones can act as substrates, and among the products, the p-methyl derivative 9a was used as a substrate to obtain different derivatives such as alcohol, amine, nitrile, and chalcone.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules27238345