The efficiency and safety of N-acetylcysteine augmentation in the autistic children with severe irritability and aggression: six cases/ Siddetli irritabilite ve saldirganligi olan otistik cocuklarda N-asetilsistein augmentasyonunun etkinligi ve guvenilirligi: Alti olgu

• Published in: Anadolu psikiyatri dergisi p. 218
• Main Authors: Onder, Arif, Adanir, Asli Surer, Coban, Ozge Gizli, Bilac, Oznur, Kara, Aziz
• Format: Journal Article
• Language: Turkish
• Published: Anadolu Psikiyatri Dergisi 01-04-2020
• Subjects: Acetylcysteine; Antioxidants (Nutrients); Aripiprazole; Autism; Autistic children; Biperiden; Development and progression; Glutamate; Oxidative stress; Safety and security measures; Social aspects
• ISSN: 1302-6631
• DOI: 10.5455/apd.53708

Autism spectrum disorder (ASD) is characterized by deficits in social interactions and communication, and restricted and stereotypic behaviors. A growing body of evidence has identified metabolic pathways and glutamatergic neurotransmission affecting oxidative stress levels as potential targets of drug development in autism spectrum disorders. N-acetylcysteine (NAC) is an antioxidant that modulate glutamate and reduce oxidative stress, both associated with the pathophysiology of ASD. N-acetylcysteine has been identified as a potential treatment agent for irritability and self-injurious behaviors in autism. In this case report, we report six cases of autism with severe symptoms of irritability and aggression, two of them responded well to N-acetylcysteine treatment, two of them responded partially and while two did not. Keywords: autism, irritability, N-Acetylcysteine, aggresion Otizm spektrum bozuklugu (OSB) sosyal-iletisimsel alanda belirgin yetersizlikler ve sinirli, yineleyici davranislar ve ilgi alanlari ile karakterizedir. Gittikce artan sayida kanit, glutamaterjik norotransmisyonu ve oksidatif stres duzeylerini etkileyen metabolik yollari otizm spektrum bozukluklarinda ilac gelisiminin potansiyel hedefleri olarak tanimlamistir. N-asetilsistein (NAC), ikisi de OSB'nin patofizyolojisi ile iliskili olarak glutamati module eden ve oksidatif stresi azaltan bir antioksidandir. N-asetilsistein, otizmde irritabilite ve kendine zarar verme davranislari icin potansiyel bir tedavi ajani olarak tanimlanmistir. Bu olgu sunumunda agir saldirganlik ve irritabilite belirtileri olan alti otizmli hastada N-asetilsistein tedavisi sunulmustur. Alti olgunun ikisi tedaviye iyi yanit verirken, diger ikisinde kismi yanit saptanmistir. Iki olgu ise tedaviye yanit vermemistir. Anahtar sozcukler: Otizm, irritabilite, N-asetilsistein, agresyon