Preparation and biological profile of .sup.99mTc-lidocaine as a cardioselective imaging agent using .sup.99mTc eluted from .sup.99Mo/.sup.99mTc generator based on Al-Mo gel

Preparation and biological profile of .sup.99mTc-lidocaine as a cardioselective imaging agent using .sup.99mTc eluted from .sup.99Mo/.sup.99mTc generator based on Al-Mo gel

The current study is aimed to prepare .sup.99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used .sup.99mTc was obtained from Al-.sup.99Mo-molybdate(VI) gel matrix. .sup.99mTc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recen...

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Bibliographic Details
Published in:Journal of radioanalytical and nuclear chemistry Vol. 314; no. 3; p. 2091
Main Authors: Sakr, Tamer M, Ibrahim, A. B, Fasih, T. W, Rashed, H. M
Format: Journal Article
Language:English
Published: Springer 01-12-2017
Subjects:
Nuclear energy
Online Access:Get full text
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Summary:The current study is aimed to prepare .sup.99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used .sup.99mTc was obtained from Al-.sup.99Mo-molybdate(VI) gel matrix. .sup.99mTc-lidocaine showed higher (15.4 ± 0.11% ID/g) and faster (15 min post injection) cardiac uptake than the recently studied .sup.99mTc-valsartan and .sup.99mTc-procainamide. Consequently, .sup.99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of .sup.99mTc-lidocaine for sodium channels in the heart.
ISSN:0236-5731
DOI:10.1007/s10967-017-5560-z