Saccharin discovery, synthesis, and applications

• Published in: Ibn Al-Haitham Journal for Pure and Applied Sciences Vol. 33; no. 2; pp. 43 - 61
• Main Authors: Mahmud, Ammar A. Razzaq, al-Jabburi, Sahar B.
• Format: Journal Article
• Language: English
• Published: بغداد، العراق جامعة بغداد، كلية التربية ابن الهيثم 2020
• Subjects: التخليق الكيميائي; المحليات الصناعية; المسرطنات
• ISSN: 1609-4042; 2521-3407
• DOI: 10.30526/33.2.2442

Saccharin is firstly synthesized in 1879. It is a very well-known as an inexpensivesubstitute for sugar as it is a non-caloric sweetener. The article shows the properties, use, metabolism and various synthesis and reactions of saccharine. Moreover, the toxicologicalreports explain that saccharin is mostly responsible for the bladder tumors observed in themale rats, the relationship between the consumption of saccharin and bladder cancer isafforded by epidemiological studies. The benefit-risk evaluation for saccharin is hardly toindicate. Saccharin is a sugar substitute, frequently used either in food industry, or inpharmaceutical formulations and even in tobacco products. The chemistry of saccharin isinteresting because of it suspected carcinogenous character and the possible use as an antidotefor metal poisoning. It appears prudent to evaluate their main properties and applicationsfurther.