In Tune with the World Trends: Clinical Aspects of Liraglutide Use in Combination with Insulin in Patients with Diabetes Mellitus (Literature Review and Clinical Observations)

In Tune with the World Trends: Clinical Aspects of Liraglutide Use in Combination with Insulin in Patients with Diabetes Mellitus (Literature Review and Clinical Observations)

There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages and limitations of a new class of antidiabetic drugs — glucagon-like peptide-1 receptor agonists, their clinical use in combination with ins...

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Published in:Miz︠h︡narodnyĭ endokrynolohichnyĭ z︠h︡urnal Vol. 12; no. 7.79; pp. 35 - 43
Main Authors: O.V. Korpacheva-Zinych, N.M. Kushnariova, A.V. Kovalchuk, O.V. Prybila, K.O. Shyshkan-Shyshova, N.M. Huryna, V.V. Korpachev
Format: Journal Article
Language:English
Published: Zaslavsky O.Yu 01-10-2016
Subjects:
diabetes mellitus
glucagon-like peptide-1
incretin mimetics
insulin therapy
obesity
review
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Abstract There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages and limitations of a new class of antidiabetic drugs — glucagon-like peptide-1 receptor agonists, their clinical use in combination with insulin, allowing to neutralize the negative effects of the latter. Liraglutide successful clinical use is described in patients suffering from diabetes mellitus type 2 in cases of ineffectively controlled fasting glucose, in the absence of glycemia compensation with high doses of insulin and metformin, as well as in cardiorenal syndrome.
AbstractList There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages and limitations of a new class of antidiabetic drugs — glucagon-like peptide-1 receptor agonists, their clinical use in combination with insulin, allowing to neutralize the negative effects of the latter. Liraglutide successful clinical use is described in patients suffering from diabetes mellitus type 2 in cases of ineffectively controlled fasting glucose, in the absence of glycemia compensation with high doses of insulin and metformin, as well as in cardiorenal syndrome.
Author N.M. Huryna
O.V. Prybila
K.O. Shyshkan-Shyshova
A.V. Kovalchuk
N.M. Kushnariova
O.V. Korpacheva-Zinych
V.V. Korpachev
Author_xml – sequence: 1
  fullname: O.V. Korpacheva-Zinych
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  fullname: N.M. Kushnariova
  organization: State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», Kyiv
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  fullname: A.V. Kovalchuk
  organization: State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», Kyiv
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  fullname: O.V. Prybila
  organization: State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», Kyiv
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  fullname: K.O. Shyshkan-Shyshova
  organization: State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», Kyiv
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  fullname: N.M. Huryna
  organization: State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», Kyiv
– sequence: 7
  fullname: V.V. Korpachev
  organization: State Institution «Institute of Endocrinology and Metabolism named after V.P. Komisarenko of the National Academy of Medical Sciences of Ukraine», Kyiv
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Snippet There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages...
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SubjectTerms diabetes mellitus
glucagon-like peptide-1
incretin mimetics
insulin therapy
obesity
review
Title In Tune with the World Trends: Clinical Aspects of Liraglutide Use in Combination with Insulin in Patients with Diabetes Mellitus (Literature Review and Clinical Observations)
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