In Tune with the World Trends: Clinical Aspects of Liraglutide Use in Combination with Insulin in Patients with Diabetes Mellitus (Literature Review and Clinical Observations)

There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages and limitations of a new class of antidiabetic drugs — glucagon-like peptide-1 receptor agonists, their clinical use in combination with ins...

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Bibliographic Details
Published in:	Miz︠h︡narodnyĭ endokrynolohichnyĭ z︠h︡urnal Vol. 12; no. 7.79; pp. 35 - 43
Main Authors:	O.V. Korpacheva-Zinych, N.M. Kushnariova, A.V. Kovalchuk, O.V. Prybila, K.O. Shyshkan-Shyshova, N.M. Huryna, V.V. Korpachev
Format:	Journal Article
Language:	English
Published:	Zaslavsky O.Yu 01-10-2016
Subjects:	diabetes mellitus glucagon-like peptide-1 incretin mimetics insulin therapy obesity review
Online Access:	Get full text
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Summary:	There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages and limitations of a new class of antidiabetic drugs — glucagon-like peptide-1 receptor agonists, their clinical use in combination with insulin, allowing to neutralize the negative effects of the latter. Liraglutide successful clinical use is described in patients suffering from diabetes mellitus type 2 in cases of ineffectively controlled fasting glucose, in the absence of glycemia compensation with high doses of insulin and metformin, as well as in cardiorenal syndrome.
ISSN:	2224-0721 2307-1427
DOI:	10.22141/2224-0721.7.79.2016.86417