HFrEF subphenotypes based on 4210 repeatedly measured circulating proteins are driven by different biological mechanismsResearch in context

Background: HFrEF is a heterogenous condition with high mortality. We used serial assessments of 4210 circulating proteins to identify distinct novel protein-based HFrEF subphenotypes and to investigate underlying dynamic biological mechanisms. Herewith we aimed to gain pathophysiological insights a...

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Bibliographic Details

Published in:	EBioMedicine Vol. 93; p. 104655
Main Authors:	Teun B. Petersen, Marie de Bakker, Folkert W. Asselbergs, Magdalena Harakalova, K. Martijn Akkerhuis, Jasper J. Brugts, Jan van Ramshorst, R. Thomas Lumbers, Rachel M. Ostroff, Peter D. Katsikis, Peter J. van der Spek, Victor A. Umans, Eric Boersma, Dimitris Rizopoulos, Isabella Kardys
Format:	Journal Article
Language:	English
Published:	Elsevier 01-07-2023
Subjects:	Biomarkers Heart Failure Phenotypes Proteomics Unsupervised machine learning
Online Access:	Get full text
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