Correlation of Shearing Force and Estradiol with Hypertension

• Published in: Zhongguo quanke yixue Vol. 26; no. 20; pp. 2469 - 2475
• Main Author: YU Tong, YANG Yi, DU Shihong, DING Zihao, HONG Xiuqin
• Format: Journal Article
• Language: Chinese
• Published: Chinese General Practice Publishing House Co., Ltd 01-07-2023
• Subjects: hypertension|estradiol|shearing force|hemodynamics|root cause analysis
• ISSN: 1007-9572
• DOI: 10.12114/j.issn.1007-9572.2023.0008

Background Low shearing force can induce vascular inflammatory response, which leads to the occurrence and development of hypertension. Estrogen can regulate the immune system and inflammatory response through estrogen receptor mediated pathway, with a protective effect on hypertension. Cardiovascular diseases have become the leading cause of death in China. Objective To investigate the current prevalence and influencing factors of hypertension in women, explore the correlation of shearing force and estradiol with hypertension as well as the effect of estradiol on hypertension under various shearing force, so as to further explore the effect of the interaction between estradiol and shearing force on hypertension. Methods Female patients admitted to the Department of Cardiology of Hunan People's Hospital from January to August 2021 were selected as the study subjects, 288 of whom with essential hypertension were included as the case group, and 296 female non-hypertensive medical examiners in the physical exami