Glutamate receptors may not protect against oxidative stress in C. elegans

Glutamate receptors may not protect against oxidative stress in C. elegans

Oxidative stress is considered a significant contributor to cellular damage, which may accumulate and result in cellular and organism senescence and death. Oxidative stress and damage have been correlated with a number of central nervous system (CNS) disorders in mammals, like Alzheimer’s and Parkin...

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Bibliographic Details
Published in:Impulse (Columbia, S.C.) p. 1
Main Authors: Alicia N. Minniti, Eryn Fennelly, Brenna Duffy, Natausha Davis, Elizabeth Chatburn, Nibaldo C. Inestrosa, Rebecca E. Kohn
Format: Journal Article
Language:English
Published: Appalachian State University Honors College 01-01-2012
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Summary:Oxidative stress is considered a significant contributor to cellular damage, which may accumulate and result in cellular and organism senescence and death. Oxidative stress and damage have been correlated with a number of central nervous system (CNS) disorders in mammals, like Alzheimer’s and Parkinson’s diseases. Using the model organism Caenorhabditis elegans, the current study investigates the survival of mutant C. elegans strains under oxidative stress. Using strains containing mutations in the glr-1 and nmr-1 genes encoding subunits of ionotropic glutamate receptors, we found no significant differences of survival among wild type (WT) and glutamate receptor mutants, though prior research has suggested the involvement of glutamatergic neurons in antioxidant defenses.
ISSN:1934-3361
1934-3361