Leukocytosis and Heart Failure in Acute Myocardial Infarction

• Published in: Majallah-i dānishkadah-i pizishkī-i Iṣfahān. (Online) Vol. 25; no. 86; pp. 69 - 62
• Main Authors: Rahimeh Eskandarian, Raheb Ghorbani, Mojtaba Malek, Zahra Asgary, Mohsen Darabian, Mehrdad Zahmatkesh
• Format: Journal Article
• Language: Persian
• Published: Isfahan University of Medical Sciences 01-01-2008
• ISSN: 1027-7595; 1735-854X

BACKGROUND: Mortality of Myocardial Infarction (MI) may due to arrhythmia or pump failure. Leukocytosis especially neutrophilia is a feature of inflammatory response. This study was performed to evaluate the association between leukocytosis at time of admission and further heart failure after the acute MI. METHODS: This case-control study performed among patients with acute MI. In patients referred to the hospital during first 24 hours of chest pain, blood sample was achieved for measuring cardiac enzymes and blood cell count. Echocardiography was performed after 3-5 days. A number of 69 patients with ejection fraction65%) was observed in 69.6% and 34.8% of patients in case and control groups, respectively (p<0.0001). There was significant relationship between leukocytosis and neutrophilia and future heart failure. Monocytosis (monocyte>2%) was seen in 33.3% and 40.6% of patients in case and control groups, respectively (p=0.3). CONCLUSION: Leukocytosis and neutrophilia can be considered as predicting factors for heart failure in acute phase of MI and it can be used for determining the risk of heart failure in those patients. KEY WORDS: Leukocytosis, neutrophilia, monocytosis, myocardial infarction, heart failure