Ingestion of Caustic Substances in Adults: A Review Article

• Published in: Iranian journal of toxicology Vol. 6; no. 19; pp. 723 - 734
• Main Authors: Andon Chibishev, Zanina Pereska, Vesna Chibisheva, Natasa Simonovska
• Format: Journal Article
• Language: English
• Published: Arak University of Medical Sciences 01-02-2013
• Subjects: Caustic agents; Esophageal Lesions; Esophagogastroduodenoscopy; Post-Corrosive Injuries
• ISSN: 2008-2967; 2251-9459

Background: Ingestion of caustic agents can cause serious damages of the upper gastrointestinal tract and in some cases this kind of poisoning may have fatal outcomes. Acute caustic intoxications are one of the main problems in the modern clinical toxicology since they mainly affect young people with psychic disorders, suicidal intent, and alcohol addiction. Text: In diagnostic evaluation of this kind of poisoning, different procedures are used. Today’s golden standard for determination of the grade and extent of the lesion is esophagogastroduodenoscopy (EGD) performed in the first 12-24 hours following corrosive ingestion. In some patients, some late complications, such as esophageal stenosis and gastric stenosis, which are the most common, as well as carcinoma of the upper gastrointestinal tract, which is rarely seen, can be detected. Acute caustic poisonings are treated with specific kinds of protocols. According to them, first, an attempt is made to neutralize the poison. Combinations of antibiotics, anti-secretory drugs, and collagen synthesis inhibitors are used. As a support therapy, nutritional liquids can be utilized, and in the most unmanageable cases, esophageal dilatation, stent placement and surgery are used. Conclusion: In the future, caustic poisonings will remain a serious socio-medical issue, due to the difficult clinical presentation, expensive diagnostic protocol, extended hospitalization, and possible permanent disability.