Emprego de compostos organometálicos mononucleares de paládio(II) na ativação de macrófagos peritoneais de camundongos Activation of mice peritoneal macrophages by palladium(II) organometallic mononuclear compounds

• Published in: Química nova Vol. 28; no. 3; pp. 405 - 408
• Main Authors: Eduardo Tonon de Almeida, Antonio Eduardo Mauro, Anderson Martinez Santana, Adelino Vieira de Godoy Netto, Iracilda Zeppone Carlos
• Format: Journal Article
• Language: English
• Published: Sociedade Brasileira de Química 01-06-2005
• Subjects: hydrogen peroxide; macrophages; palladium(II) complexes
• ISSN: 0100-4042; 1678-7064
• DOI: 10.1590/S0100-40422005000300008

The immune responses are mediated by a variety of cells that, when activated, produce a number of molecules. Macrophages are the first cells to take part in the immune response releasing many compounds in the extracellular environment such as H2O2. Taking into account this aspect we evaluated the activation of an immunological system, in vitro, by determining the H2O2 released in cultures of peritoneal macrophage cells from Swiss mice in the presence of organopalladated compounds of the type [Pd(dmba)(X)(dppp)], dmba = N,N-dimethylbenzylamine, dppp = 1,3-bis(diphenylphosphine)propane, X = Cl, N3, NCO, NCS. An excellent activation of macrophages by the [Pd(dmba)(X)(dppp)] compounds was observed and the influence of the X ligand on the immune response could be verified.