Evaluation of the new marker interleukin - 33 in Iraqi female patients with hyperthyroidism

• Published in: Journal of the Faculty of Medicine, Baghdad Vol. 55; no. 2
• Main Author: Bushra H. Ali
• Format: Journal Article
• Language: English
• Published: College of Medicine University of Baghdad 01-07-2013
• Subjects: Hyperthyroidism, Interlukin-33, Thyroxin, Thyroid stimulating hormone
• ISSN: 0041-9419; 2410-8057
• DOI: 10.32007/jfacmedbagdad.v2170-174%

Background: Hyperthyroidism refers to overactive of thyroid gland leading to excessive synthesis of thyroid hormones and accelerated metabolism in the peripheral tissue. Objective: The aim of this study is to evaluate a new member of the IL-1 super family of cytokines interleukin-33(IL-33) levels in serum .in order to evaluate its utility as clinical bio marker of autoimmune disease (i.e. hyperthyroidism) Methods: The present study was conducted on 30 patients from the Iraqi female patients with hyperthyroidism attending Baghdad teaching hospital, in addition to 30 healthy controls. All subjects were (35-65) years old. Parameters measured in the sera of patients and healthy groups, were interleukin -33 (IL-33), Thyroxin (T4), Thyroxin (T3) and Thyroid stimulating hormone TSH. Results: A new member of super family cytokines Interleukin -33 was determined in hyperthyroidism, female patients. Higher significant elevation was found when compared with healthy control. Conclusion: From this study a conclusion was drawn, that evaluation of concentration of a new super family cytokines IL-33 could consider as a clinical biomarkers in hyperthyroidism female patients. This finding may indicate that autoimmune disease like hyperthyroidism might influence cytokine like interleukin -33 production in these patients