Impact of Biphasic Calcium Phosphate mixed with injectable platelet rich fibrin (i-PRF) on bone density in surgically created bone defects in a sheep animal model (A Radiographic Assessment)

• Published in: Maǧallaẗ al-rāfidayn li-ṭibb al-asnān Vol. 23; no. 2; pp. 238 - 245
• Main Authors: Junayna H. Ali, Rayan S. Hamed
• Format: Journal Article
• Language: Arabic
• Published: University of Mosul, College of Dentistry 01-09-2023
• Subjects: biphasic calcium phosphate; bone density; injectable platelet rich fibrin
• ISSN: 1812-1217; 1998-0345
• DOI: 10.33899/rdenj.2022.133155.1157

Aims: To assess bone density means with Biphasic calcium phosphate alone or mixed with injectable platelet-rich fibrin in bone defects created surgically in sheep’s tibia / radius using standard radiographic assessment. Materials and Methods: Three bony defects of 4mm full and 7 mm in diameter were created in every tibias/radius of five sheep. The defects were stuffed within the following order: from a proximal to distal orientation; 1st defect was full of biphasic calcium phosphate alone, the second was left empty to be filled by physiological clot and also the third with i-PRF mixed with BCP and covered with absorbable collagen membrane for tissue guiding and then sutured. Densitometric analysis of bone defects was made to measure density of bone at four-time intervals (two, four, six and eight weeks) post-surgically. Results: Densitometric analysis results showed a major distinction within the BCP+i-PRF group and BCP group compared with the control one and at all-time intervals with the best density being in the 1st group followed by the BCP alone group and least in the control group. Conclusions: BCP and i-PRF, both of them increased and sustained bone density (synergistic effect) throughout the study period as revealed by densitometric data.