Synthesis of new 3,5-substiuted isoxazole derivatives possessing potential anti-aggregative activity

Synthesis of new 3,5-substiuted isoxazole derivatives possessing potential anti-aggregative activity

Two new compounds belonging to 3,5-substituted isoxazoles class were synthesized for the action mechanism investigation and the pharmacophore fragment determination of potential anti-aggregative compounds of this class. An attempt to prepare of 5-phenyl-3-(3-pyridyl)isoxazole by the phase-transfer m...

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Bibliographic Details
Published in:Tonkie himičeskie tehnologii (Online) Vol. 5; no. 6; pp. 47 - 51
Main Authors: O. V. Demina, A. V. Laptev, A. U. Lukin, N. E. Belikov, K. V. Zvezdin, M. A. Fomin, A. A. Khodonov, S. D. Varfolomeev, V. I. Shvets
Format: Journal Article
Language:Russian
Published: MIREA - Russian Technological University 01-12-2010
Subjects:
3,5-substituted isoxazoles
3-pyridinaldoxime
[3+2] cycloaddition
phase-transfer catalysis
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Summary:Two new compounds belonging to 3,5-substituted isoxazoles class were synthesized for the action mechanism investigation and the pharmacophore fragment determination of potential anti-aggregative compounds of this class. An attempt to prepare of 5-phenyl-3-(3-pyridyl)isoxazole by the phase-transfer method was described.
ISSN:2410-6593
2686-7575