Comparative characterization of oxidative stress in cervical cancer at different clinical stages of disease

• Published in: Opukholi zhenskoĭ reproduktivnoĭ sistemy no. 4; pp. 55 - 58
• Main Authors: I. I. Antoneeva, T. P. Gening, D. R. Arslanova, E. G. Sidorenko
• Format: Journal Article
• Language: Russian
• Published: ABV-press 01-08-2014
• Subjects: catalase; cervical cancer; glutathione-reductase; glutathione-transferase; malondialdehyde; oxidative stress; superoxide-dismutase
• ISSN: 1994-4098; 1999-8627
• DOI: 10.17650/1994-4098-2011-0-4-55-58

Parameters of oxidative stress on the level of malondialdehyde (MDA), activity of glutathione-reductase, glutathione-transferase, superoxide- dismutase (SOD) and catalase in tumor tissue, plasma and red blood cells of patients with cervical cancer (CC) w as evaluated a t various clinical stages of the disease. It is revealed that an increase in tumor tissue MD A and glutathione enzymes while reducing SOD and catalase, which may indicate the development of oxidative stress in the dynamics of tumor progression. The data obtained suggest the increase of expres- sion of oxidative stress in red blood cells and tumor tissue in CC in the dynamics of tumor progression.