Experimental study of the acute toxicity of the oral form of pegylated interferon α2-b

The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods. The preparation was orally administered to mice and rats at calculated therapeutic doses and do...

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Bibliographic Details
Published in:	Sibirskiĭ nauchnyĭ medit︠s︡inskiĭ zhurnal Vol. 38; no. 1; pp. 12 - 16
Main Authors:	D. N. Kinsht, P. G. Madonov, T. S. Tartynova, A. A. Churin, E. Y. Sherstoboev
Format:	Journal Article
Language:	Russian
Published:	Russian Academy of Sciences, Siberian Branch Publishing House 01-02-2019
Subjects:	acute toxicity immobilization interferon α-2b pegylation preclinical trials
Online Access:	Get full text
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Summary:	The aim of the study is to investigate the acute toxicity of the oral finished dosage form of pegylated interferon α-2b, obtained with the help of electron-beam synthesis technology. Material and methods. The preparation was orally administered to mice and rats at calculated therapeutic doses and doses exceeding them. Recorded parameters: animal death, general condition and behavior, weight of animals. Results and discussion. The drug has no toxic effect when administered orally. No macroscopic signs of gastric damage were found. The definition of LD is not possible.
ISSN:	2410-2512 2410-2520
DOI:	10.15372/SSMJ20180102