Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?

Objective: Here, possible protective effects of Urapidil were investigated against lung and renal injuries induced by cecal ligation and puncture (CLP). Materials and Methods: 32 Sprague Dawley male rats were assigned to 4 groups as follows; sham, CLP, DMSO and Urapidil (URA) 0.5 mg/kg. Several oxid...

Full description

Saved in:

Bibliographic Details
Published in:	Sakarya tıp dergisi Vol. 11; no. 1; pp. 142 - 147
Main Authors:	Ayhan Tanyeli, Derya Güzel, Songül Doğanay, Mustafa Can Güler, Ersen Eraslan
Format:	Journal Article
Language:	English
Published:	Sakarya University 01-03-2021
Subjects:	akciğer böbrek cecal ligation and puncture lung rat renal sıçan urapidil çekal ligasyon ve delme
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Objective: Here, possible protective effects of Urapidil were investigated against lung and renal injuries induced by cecal ligation and puncture (CLP). Materials and Methods: 32 Sprague Dawley male rats were assigned to 4 groups as follows; sham, CLP, DMSO and Urapidil (URA) 0.5 mg/kg. Several oxidant, inflammatory and antioxidant parameters were determined in lung and renal tissues. Results: Oxidant and inflammatory biomarkers increased while antioxidant biomarkers decreased in CLP and DMSO groups compared to sham group. Antioxidant parameters increased while oxidant and inflammatory biomarkers declined in treatment group compared to CLP and DMSO groups. Conclusion: Present results have demonstrated that URA administration is effective against lung and renal injuries caused by CLP-related polymicrobial sepsis model.
ISSN:	2146-409X
DOI:	10.31832/smj.787082