Intradialytic Parenteral Nutrition in Patients on Hemodialysis: A Multicenter Retrospective Study

• Published in: Nutrients Vol. 16; no. 23; p. 4018
• Main Authors: Arias-Guillén, Marta, González, Juan Carlos, Betancourt, Loreley, Coll, Elisabeth, Collado, Silvia, Romano-Andrioni, Bárbara, Lupiañez-Barbero, Ascensión, Garro, Julia, Duarte, Verónica, Soler-Majoral, Jordi, Calabia, Jordi
• Format: Journal Article
• Language: English
• Published: 24-11-2024
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16234018

Background and Objective: To evaluate the effectiveness and safety of intradialytic parenteral nutrition (IDPN) on different nutritional outcomes. Methods: This was a retrospective analysis for a “routinely collected data bank” in a multicenter cohort, conducted on consecutive malnourished or at-risk of malnutrition patients with chronic kidney disease on hemodialysis who underwent IDPN with a three-in-one parenteral nutrition formula for a period ≥ 2 weeks. The primary endpoint was the mean change in the malnutrition inflammation score (MIS) score between baseline and the last follow-up visit on IDPN. Results: Fifty-six patients were included. The mean age was 72.4 ± 12.0 years, and 24 (42.9%) were women. In the overall study sample, MIS significantly decreased from 16.4 (95%CI: 15.3–17.65) at baseline to 14.3 (95%CI: 12.8–15.8) at the last follow-up visit on IDPN (p = 0.0019). Fifteen (26.8%) patients achieved a MIS reduction ≥ 5 points after IDPN. As compared to baseline, IDPN significantly reduced the proportion of patients with protein-energy wasting (PEW) (89.3% versus 66.1%, respectively, p = 0.0023). Regarding analytical parameters, serum albumin (p = 0.0003) and total proteins (p = 0.0024) significantly increased after IDPN administration. Throughout the study’s follow-up period, 45 (80.4%) patients reported experiencing some type of adverse event. Conclusions: IDPN was associated with a significant improvement in the nutritional profile. Notably, our research found that the administration of IDPN over a duration > 3 months significantly improved the nutritional status of patients evaluated by the MIS test.