Abstract TP21: Safety of Cangrelor in Emergency Endovascular Stroke Recanalization, a Single Center Experience

• Published in: Stroke (1970) Vol. 51; no. Suppl_1
• Main Authors: Vanguru, Husitha Reddy, Albright, Karen C, Ahmed, Rashid, Gould, Grahame, Masoud, Hesham, Latorre, Julius G
• Format: Journal Article
• Language: English
• Published: 01-02-2020
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/str.51.suppl_1.TP21

Abstract only
Introduction:
Optimal antiplatelet regimen post-emergent stenting in acute stroke remains challenging among patients at high-risk for thrombosis and/or hemorrhage, especially after tPA. We describe our preliminary experience with cangrelor, an immediate acting IV P2Y12 receptor inhibitor with rapid onset and clearance.
Methods:
Retrospective cross-sectional study of mechanical thrombectomy (MER) patients requiring urgent stenting(0-48h). Patients treated with cangrelor were compared to those treated with other antiplatelets.
Results:
Nine cangrelor patients were compared to twelve patients treated with other antiplatelets. Pre- and post-treatment measures were similar overall (Table).
Conclusions:
Cangrelor may be a safe alternative to current antiplatelets used in immediate perioperative period post-MER and urgent stenting, including tPA patients and those at high-risk for malignant cerebral edema or hemorrhagic transformation. Additional studies are required to confirm or refute our observations.