Abstract T P267: Admission Hemoglobin and Sodium Values are Important Factors Associated with Good Outcome After Acute Ischemic Stroke

• Published in: Stroke (1970) Vol. 46; no. suppl_1
• Main Authors: Cohen, Abigail S, Siddiqui, Khawja A, Ali, Syed F, Anderson, Christopher D, Silverman, Scott B, Schwamm, Lee H
• Format: Journal Article
• Language: English
• Published: 01-02-2015
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/str.46.suppl_1.tp267

Abstract only
Introduction:
Prognostic factors in patients with acute ischemic stroke (AIS) are useful in assessing therapeutic interventions. Our aim was to investigate if commonly measured admission lab values (BUN, creatinine, hemoglobin, INR, platelets, and sodium) added value to models built using only clinical variables in predicting outcome after AIS.
Methods:
We included 5,886 consecutive patients from 12/2002 to 5/2014 in our local Get with the Guidelines-Stroke registry in whom labs collected within two days of admission could be extracted from an administrative research data registry (RPDR). Univariate and multivariable analyses were performed to identify predictors of good outcome, defined as discharge to home.
Result:
Among 5,886 patients, 2340 (39.7%) had a good outcome. In unadjusted analyses, patients with good outcomes were more often younger and male, had a lower median NIHSS and fewer vascular risk factors, except they were more often smokers. They underwent IV and IA thrombolysis less often. After adjustment for clinical and hyperacute variables present on admission, increasing age, male gender and NIHSS, diabetes, prior stroke/TIA, atrial fibrillation and heart failure independently reduced the odds of a good outcome; but IV tPA use nearly doubled it. Additional adjustment for lab values further attenuated some variables (e.g., heart failure), and increasing hemoglobin and sodium independently increased the odds of a good outcome (Table 2).
Conclusion:
Many factors impact the likelihood of good outcome following acute ischemic stroke. Our study shows that hemoglobin and sodium on admission may add important prognostic information.