Abstract P370: Nocturnal Blood Pressure Fall on Ambulatory Monitoring in a Cohort Data of Elderly Subjecsts

• Published in: Hypertension (Dallas, Tex. 1979) Vol. 70; no. suppl_1
• Main Authors: Lopes, Patricia d, Rodrigues, Livia F, Prado, Yasmin S, Rocha, Ligia d, Almeida, Paulo E, Lucci, Maria A, dos Santos, Mariella P, Costa, Lílian S
• Format: Journal Article
• Language: English
• Published: 01-09-2017
• ISSN: 0194-911X; 1524-4563
• DOI: 10.1161/hyp.70.suppl_1.p370

Abstract only
Introduction:
The use of Ambulatory Blood Pressure Monitoring has offered parameters that directly support stratification and independent association of cardiovascular risk (CV), especially in the elderly.
Objective:
To evaluate systolic (SBP) and diastolic (DBP) patient’s blood pressure (BP) on 24-hour, daytime and night time periods, pulse pressure (PP) and systolic and diastolic nocturnal drop in a population of elderly referred to be clinically healthy.
Method:
In a cohort of 1652 individuals over 60 years of age, both genders, we selected 434 subjects with no prior history of CV disease and off CV medications. Of these, 242 (56%) had normal and 192 (44%) had elevated mean 24-hour BP (G2), being 68 with isolated systolic hypertension (G2A) and 124 with systolic and diastolic hypertension (G2B). Analysis of variance was applied for a comparative study between groups, assuming a significance level of
p
less than 0.05.
Results:
Mean 24-hour, daytime and night time SBP in G1 were 118.94 ± 7.2, 122.27 ± 3.0, 110.23 ± 4.1 mmHg in men and 117.05 ± 6.3, 120, 46 ± 2.4 and 107.57 ± 3.4 mmHg in women (p = 0.06). Mean DBP values in the same periods were, respectively, 67.66 ± 6.62, 70.61 ± 5.3 and 60.24 ± 2.4 mmHg in men and 67.94 ± 5.2, 70.70 ± 5, 2 and 60.57 ± 5.1 mmHg in women (p = 0.08). Statistical analysis showed no difference for PP values between genders in different periods evaluated. In G2, there was a significant difference between subgroups A and B for all parameters, with mean 24-hour BP being 137,18x71,85 in G2A and 142,67x86,33 in G2B, p 0.003 SBP and 0.001 DBP, and 24-hour PP 65.32 and 56.33 mmHg, respectively (P 0.001), with no significant difference between genders. Regarding mean systolic and diastolic nocturnal drop, we observed values in G1 10,06 ± 7,07 and 14,37 ± 8,18, in G2A 5,24 ± 10,2 and 9,73 ± 9,8 and in G2B 8,93 ± 6.47 and 13.36 ± 6.5 mmHg, respectively; that is, lower values in G2A compared to G1 and G2B (p 0.001 and p 0.033), with G1 and G2B with no significant difference.
Conclusions:
Since the nocturnal drop pattern is the most consistent predictor of CV outcome, we have confirmed in our findings, previous literature data, which shown reduced nocturnal BP falls in the elderly population as a marker of BP elevation itself, after adjusting for age, gender and comorbidities.