Abstract 14382: Association of Atherosclerotic Plaque Burden and FFR CT- Serial Cardiac CTA Study

• Published in: Circulation (New York, N.Y.) Vol. 144; no. Suppl_1
• Main Authors: Shaikh, Kashif, Kinninger, April, Dahal, Suraj, Lakshmanan, Suvasini, Golub, Ilana, ALLA, VENKATA M, Leipsic, Jonathon, Budoff, Matthew
• Format: Journal Article
• Language: English
• Published: 16-11-2021
• ISSN: 0009-7322; 1524-4539
• DOI: 10.1161/circ.144.suppl_1.14382

Abstract only
Introduction:
Cross-sectional studies have shown the association of atherosclerotic plaque burden and FFR
CT
. However, the relationship between changes in anatomic CCTA parameters and FFR
CT
has not been evaluated. In the present study, we sought to study the natural history of FFR
CT
and to observe the impact of coronary plaque characteristics on intracoronary hemodynamics over time as assessed by noninvasive CCTA.
Methods:
Patients who had undergone baseline and follow-up CCTA were included. Coronary plaque scores and vessel stenosis severity were quantified on CCTA. Multivariate linear regression was used to examine the association of change in the per vessel FFR
CT
, average distal FFR
CT,
and the most diseased vessel FFR
CT
with total plaque score(TPS), coronary artery calcium(CAC), total segment stenosis (TSS), segment involvement score (SIS).
Results:
Final analysis included 101 subjects (83% male; age 65.5 ± 10.1 years). After adjusting for several cardiovascular risk factors, on a per-vessel basis involving the most significant lesion, a 1 unit increase in TPS resulted on average in a 0.008 decrease in FFR in the most diseased vessel, p=0.004, after adjusting for several risk factors. Using the average FFR
CT
of the distal LAD, RCA, and LCX, a 1 unit increase in TPS results on average in a 0.004 decrease in the distal average FFR, p=0.026. A 1 unit increase in TPS results on average in 0.005 decrease in the RCA distal pins of FFR, p=0.033 (Table 1). There are no significant associations of the LCX and LAD FFR with TPS. There are no significant associations of the change in FFR
CT
with TSS, SIS or CAC progression.
Conclusion:
Worsening atherosclerotic plaque burden is associated with worsening physiology as assessed on CCTA as assessed by FFR
CT
. Therapies that stabilize or regress plaque may improve overall physiology. Further prospective trials are required to validate these findings.