Abstract 3187: Utility of serum p53 antibodies in patients with various types of malignant tumors

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 8_Supplement; p. 3187
• Main Authors: Hagiwara, Nobutoshi, Miyashita, Masao, Yamashita, Naoyuki, Iida, Shinya, Nomura, Tsutomu, Makino, Hiroshi, Okawa, Keiichi, Takahashi, Ken, Akagi, Ichiro, Shinozuka, Eriko, Fujita, Itsuro, Kanazawa, Yoshiichi, Sakurazawa, Nobuyuki, Onodera, Hiroyuki, Uchida, Eiji
• Format: Journal Article
• Language: English
• Published: 15-04-2011
• ISSN: 0008-5472; 1538-7445
• DOI: 10.1158/1538-7445.AM2011-3187

Abstract
Background: Circulating anti-p53 antibody(p53-Ab) in blood can be detected in various cancers. Serum p53-Ab has been applied as a tumor marker in clinical practice. We studied the clinical significance of p53-Ab in patients with esophageal, colorectal, and breast carcinoma.
Methods: p53-Ab in serum was measured with Enzyme-linked immunosorvent assay (ELISA) before treatment in 51 patients with esophageal carcinoma, 54 patients with colorectal carcinoma, and 84 patients with breast carcinoma. clinical and pathological features of these cancers
The association between clinicopathological factors of these cancers and the level of p53-Ab in serum was evaluated.
Results: Twenty-one(41%) of 51 patients with esophageal cancer, 23 (42%) of 54 with colorectal cancer, and 26 (30%) of 84 with breast cancer were diagnosed as p53-Ab positive according to the Manufacture's cut-off value. p53-Abs in serum were observed in all these cancer patients with earlier stage. Positive p53-Ab cases in esophageal, colorectal, and breast cancer in stage I were 33%, 25%, and 35%, respectively. There was no correlation between the positive cases and the age, sex, lymph node metastases, distant metastases, or tumor stage.
Conclusion: This study showed that p53-Ab in serum was frequently detected in patients with esophageal, colorectal, and breast cancer. p53-Ab can be a promising tumor marker for the early detection of these cancers.
Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 3187. doi:10.1158/1538-7445.AM2011-3187