A colorimetric and fluorescent signaling probe for assaying Pd 2+ in practical samples

• Published in: RSC advances Vol. 13; no. 45; pp. 31962 - 31968
• Main Authors: Choi, Myung Gil, Han, Juyoung, Ahn, Sangdoo, Chang, Suk-Kyu
• Format: Journal Article
• Language: English
• Published: 26-10-2023
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/D3RA05549C

We developed an optical signaling probe to detect Pd
2+
ions in Pd-containing catalyst and drug candidate. The Pd
2+
signaling probe (Res-DT) was readily prepared by reacting the versatile fluorochrome resorufin with phenyl chlorodithioformate. In a phosphate-buffered saline solution (pH 7.4) containing sodium dodecyl sulfate (SDS) as a signal-boosting surfactant, Res-DT exhibited a pronounced colorimetric response with a chromogenic yellow to magenta shift, leading to a substantial increase in the fluorescence intensity. The Pd
2+
signaling performance of Res-DT was attributed to the Pd
2+
-promoted hydrolysis of the dithioate moiety. The probe displayed high selectivity toward Pd
2+
ions and remained unaffected by commonly encountered coexisting components. Moreover, the detection limit of Res-DT for Pd
2+
ions was 10 nM, and the signaling was achieved within 7 min. Furthermore, to demonstrate the real-world applicability of Res-DT, a Pd
2+
assay was performed in Pd-containing catalyst and drug candidate using an office scanner as an easily accessible measurement device. Our results highlight the prospects of Res-DT as a tool to detect Pd
2+
ions in various practical samples, with potential applications in catalysis, medicine, and environmental science.