体外及体内实验证明高丽参浆果提取物（GB0710）对阴茎勃起的影响
不少报道证实传统的高丽红参（KRG）可以作为勃起功能障碍的替代治疗手段，而高丽参中最为有效的成分即是人参皂。近来的研究表明高丽参浆果中产生的人参皂苷高于高丽参。因此，我们研究了高丽参浆果提取物（GB0710）对阴茎海绵体平滑肌的舒缓作用，我们使用高丽参提取物作为对照组。另外我们还研究了GB0710可能的作用机制。预收缩的兔子的阴茎海绵体平滑肌的体外实验证明KRG和GB0710部具有剂量依赖的舒缓肌肉作用，但GB0710效果更强，GB0710引起的舒缓会由于内皮细胞的移除而减弱。另外，使用儿种一氧化氮抑制剂预处理后，会显著抑制肌肉束的舒缓。进一步研究发现，在大鼠体内模型下，使用GB0710会引起...
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| Published in: | 亚洲男性学杂志：英文版 no. 4; pp. 503 - 507 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | 不少报道证实传统的高丽红参（KRG）可以作为勃起功能障碍的替代治疗手段，而高丽参中最为有效的成分即是人参皂。近来的研究表明高丽参浆果中产生的人参皂苷高于高丽参。因此，我们研究了高丽参浆果提取物（GB0710）对阴茎海绵体平滑肌的舒缓作用，我们使用高丽参提取物作为对照组。另外我们还研究了GB0710可能的作用机制。预收缩的兔子的阴茎海绵体平滑肌的体外实验证明KRG和GB0710部具有剂量依赖的舒缓肌肉作用，但GB0710效果更强，GB0710引起的舒缓会由于内皮细胞的移除而减弱。另外，使用儿种一氧化氮抑制剂预处理后，会显著抑制肌肉束的舒缓。进一步研究发现，在大鼠体内模型下，使用GB0710会引起海绵体内压的上升，并呈现剂量和时间依赖。细胞内的一氧化氮产生于微管内皮细胞中，可以被GB0710诱导产生，而被NG．单甲璀-L-精氨酸抑制。总之，GB0710d 兔子海绵体平滑肌舒缓的作用强于KRG提取物，并且在大鼠模型中增加了海绵体内压，表现出了剂量和时间依赖。这一舒缓作用可能是通过一氧化氮的产生来介导的。 |
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| Bibliography: | Several reports have promoted the root-derived Korean red ginseng （KRG; Panax ginseng） as alternative treatment for erectile dysfunction （ED）, and ginsenosides are known to be the principal active ingredients of ginseng. Recent studies showed that ginseng berries produce more ginsenosides than KRG; thus, we investigated the ability of the Korean ginseng berry extract GB0710 to relax the penile corpus cavernosum smooth muscle （CCSM） in this study. As a comparative control, the results were compared to those obtained using KRG. In addition, possible mechanisms of action for GB0710 were investigated. While KRG and GB0710 both displayed dose-dependent relaxation effects on precontracted rabbit CCSM in vitro, GB0710 was shown to be more potent than KRG. The GBO710-induced relaxation could be partially reduced by removing the endothelium. In addition, pre-treatment with several nitric oxide （NO） inhibitors significantly inhibited the relaxation of muscle strips. Furthermore, administration of GB0710 increased intracavernosal pressure （ICP） in a rat in vivo model in both a dose- and duration-dependent manner. Intracellular NO production in human microvascular endothelial cells could be induced by GB0710 and inhibited by NG-monomethyI-L-arginine. In conclusion, GB0710 had a greater relaxation effect on rabbit CCSM than did KRG extract, and increased ICP in a rat model in both a dose- and a duration-dependent manner. This relaxine effect might be mediated bv NO production. corpus cavernosum; erectile dysfunction （ED）; ginseng berry; nitric oxide （NO）; smooth muscle 31-1795/R |
| ISSN: | 1008-682X 1745-7262 |