Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H_2O_2-induced oxidative damage to rat cortical neurons

Flavonoids from the stems and leaves of Scutellaria baicalensis Georgi attenuate H_2O_2-induced oxidative damage to rat cortical neurons

Primary cultures of rat cortical neurons were treated with H2O2 in an in vitro model of free radical neurotoxicity. Flavonoids extracted from the stems and leaves of Scutellaria baicalensis Georgi, known as SSF, at concentrations of 18.98, 37.36 and 75.92 μg/mL, protected neurons against H2O2 injury...

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Published in:中国神经再生研究：英文版 Vol. 6; no. 27; pp. 2100 - 2104
Main Author: Yongping Liu Kai Cao Hong Miao Jianjun Cheng Yazhen Shang
Format: Journal Article
Language:English
Published: 2011
Subjects:
ATP酶活性
大鼠
氧化损伤
皮层神经元
诱导
谷胱甘肽过氧化物酶
超氧化物歧化酶
黄酮类化合物
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Summary:Primary cultures of rat cortical neurons were treated with H2O2 in an in vitro model of free radical neurotoxicity. Flavonoids extracted from the stems and leaves of Scutellaria baicalensis Georgi, known as SSF, at concentrations of 18.98, 37.36 and 75.92 μg/mL, protected neurons against H2O2 injury in a dose-dependent manner. SSF increased cell survival, reduced lactate dehydrogenase release and inhibited malondialdehyde production. SSF also inhibited reductions in superoxide dismutase, glutathione peroxidase and Na＋-K＋-ATPase activities. These results in-dicate that SSF can protect rat cortical neurons against H2O2-induced oxidative injury.
Bibliography:flavonoids from Scutellaria baicalensis Georgi H2O2 lactate dehydrogenase superoxide dismutase malondialdehyde glutathione peroxidase Na＋-K＋-ATPase neural regeneration
Primary cultures of rat cortical neurons were treated with H2O2 in an in vitro model of free radical neurotoxicity. Flavonoids extracted from the stems and leaves of Scutellaria baicalensis Georgi, known as SSF, at concentrations of 18.98, 37.36 and 75.92 μg/mL, protected neurons against H2O2 injury in a dose-dependent manner. SSF increased cell survival, reduced lactate dehydrogenase release and inhibited malondialdehyde production. SSF also inhibited reductions in superoxide dismutase, glutathione peroxidase and Na＋-K＋-ATPase activities. These results in-dicate that SSF can protect rat cortical neurons against H2O2-induced oxidative injury.
11-5422/R
ISSN:1673-5374