Glutathione-S-transferase （GSTM1, GSTrl） and the risk of gastrointestinal cancer in a Korean population

• Published in: World journal of gastroenterology : WJG no. 45; pp. 5716 - 5721
• Main Author: Jin-Mei Piao Min-Ho Shin Sun-Seog Kweon Hee Nam Kim Jin-Su Choi Woo-Kyun Bae Hyun-Jeong Shim Hyeong-Rok Kim Young-Kyu Park Yoo-Duk Choi Soo-Hyun Kim
• Format: Journal Article
• Language: English
• Published: 2009
• Subjects: GSTM1基因; 聚合酶链反应; 胃肠道肿瘤; 谷胱甘肽S; 转移酶; 韩国人
• ISSN: 1007-9327; 2219-2840

AIM： To evaluate the association of glutathione S-trans-ferase mu （GSTM1） and glutathione S-transferase theta （GSTT1） null genotypes with the risk of gastric cancer （GC） and colorectal cancer （CRC） in a South Korean population. METHODS： We conducted a population-based, large- scale case-control study including 2213 GCs, 1829 CRCs, and 1699 controls. Null and non-null genotypes of GSTM1 and GSI-F1 were determined using realtime PCR. RESULTS： The null genotypes of GSTM1 and GSTT1 were not significantly associated with elevated risk of gastric （OR = 1.070, 95% CI = 0.935-1.224; OR = 1.101, 95% CI = 0.963-1.259, respectively） or colorectal cancer （OR = 1.065, 95% CI = 0.923-1.228; OR = 1.041, 95% CI = 0.903-1.200, respectively）. The frequency of the combined null GST genotype was not different between the two cancer groups and controls. Moreover, smoking, drinking, and age did not modify the association between these genotypes and the risk of gastric or colorectal cancer. CONCLUSION： GSTM1 and GSCI-1 null genotypes were not associated with increased risk of GC or CRC in Koreans.