Correlation of Serum and Salivary Carbamazepine Concentration in Epileptic Patients : Implications for Therapeutic Drug Monitoring
Therapeutic drug monitoring (TDM) of carbamazepine (CBZ) in saliva is an attractive alternative, because its collection is painless, non-invasive and simpler than drawing blood. Salivary drug levels, also closely reflect the free drug concentration. The aim of the study was to evaluate the suitabili...
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| Published in: | Neurology India Vol. 50; no. 1 |
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| Main Author: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
Medknow Publications on behalf of the Neurological Society of India
08-04-2003
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| Subjects: | |
| Online Access: | Get full text |
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| Summary: | Therapeutic drug monitoring (TDM) of carbamazepine (CBZ) in saliva is
an attractive alternative, because its collection is painless,
non-invasive and simpler than drawing blood. Salivary drug levels, also
closely reflect the free drug concentration. The aim of the study was
to evaluate the suitability of saliva in routine TDM of CBZ in adult
epileptic patients. Blood and saliva samples were taken simultaneously
at 0 hours and 24 hours of CBZ dosing from 31 epileptic patients,
receiving CBZ monotherapy for three or more months. Levels of CBZ in
both these fluids were measured by high performance liquid
chromatography. Strong and highly significant correlation was found
between serum and salivary CBZ concentration (r = 0.659, p<0.001).
Estimation of CBZ level in saliva is thus a practicable, valid and
convenient method of TDM in epileptic patients. |
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| ISSN: | 0028-3886 |