Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: Discovery of TR-14035, a dual α4β7/α4β1 integrin antagonist

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry Vol. 10; no. 6; pp. 2051 - 2066
Main Authors:	SIRCAR, Ila, GUDMUNDSSON, Kristjan S, CONNELL, Samuel, GRIFFITH, Ronald C, LAZARIDES, Elias, MARTIN, Richard, LIANG, Jimmy, NOMURA, Sumihiro, JAYAKUMAR, Honnappa, TEEGARDEN, Bradley R, NOWLIN, Dawn M, CARDARELLI, Pina M, MAH, Jason R
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Science 2002
Subjects:	Biological and medical sciences Immunomodulators Medical sciences Pharmacology. Drug treatments α-Aminoacid Vascular cell adhesion molecule 1 Integrin Structure activity relation Biphenyl derivatives Chlorine Organic compounds Benzenic compound Non peptide compound Inhibitor Chemical synthesis Adhesion In vitro
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ISSN:	0968-0896 1464-3391
DOI:	10.1016/S0968-0896(02)00021-4