Design, synthesis, and SAR of 2-dialkylamino-4-arylpyrimidines as potent and selective corticotropin-releasing factor1 (CRF1) receptor antagonists

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Bibliographic Details
Published in:	Bioorganic & medicinal chemistry letters Vol. 14; no. 9; pp. 2083 - 2086
Main Authors:	HUANG, Charles Q, GRIGORIADIS, Dimitri E, ZHENGYU LIU, MCCARTHY, James R, RAMPHAL, John, WEBB, Thomas, WHITTEN, Jeffrey P, XIE, Michael Y, CHEN CHEN
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier 03-05-2004
Subjects:	Biological and medical sciences Medical sciences Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Peptidergic system (neuropeptide, opioid peptide, opiates...). Adenosinergic and purinergic systems Pharmacology. Drug treatments Cyclopropane derivatives Structure activity relation CRF1 receptor Nitrogen heterocycle Chlorine Organic compounds Pyrimidine derivatives Selectivity Antagonist Chemical synthesis In vitro
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Description
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2004.02.053