Preparation of a Nanohybrid Antifungal from Griseovulvin and Zinc Oxide and Determination of Inhibitory Activity against Dermatophyte Isolates

• Published in: Journal of pharmaceutical sciences and research Vol. 10; no. 11; pp. 2783 - 2786
• Main Authors: Mahmod, Z S, Jwad, B A A, Al-Khafaji, n M
• Format: Journal Article
• Language: English
• Published: Cuddalore Journal of Pharmaceutical Sciences and Research 01-11-2018
• Subjects: Nanoparticles; Pharmaceuticals; Skin; Zinc oxides
• ISSN: 0975-1459

More specifically, the current study aimed to prepare a nanohybrid antifungal from griseovulvin (also spelled griseofulvin) and restore its efficacy in the face of growing resistance. 2.Materials and methods 2.1Preparation of antifungal nanoparticales from zinc oxide and griseovulvin by Sol gel ion exchange The antifungal ZnO nanoparticles were prepared from griseovulvin and zinc oxide layers by the sol-gel ion exchange method which was modified from Kolekar et al., [12]. [...]the dried product (precipitate) was grinded and stored in refrigerator. 2.2Nanohybrid antifungal diagnosis (screening). 2.2.3 Nanoantifungal using atomic force microscope (AFM) The AFM was used to test the nanohybrid antifungal Gri-ZnO and measured the diameter, size, and nanoparticles' grouping. The crystallity index of the nanohybrid antifungal was found to be 1.75 according to data in Table 1 and XRD spectrum (Figure 5).The current study agreed with another study [15], where the prepared spherical shape of the nanohybrid molecules size (5076nm) is similar. 4.3Inhibition activity of nanohybrid antifungal Gri-ZnO against dermatophyte isolates The inhibition activity against 12 dermatophyte isolates (numerated from 1 to 12) wasstudiedin vitro.The dermatophyte isolates included six strains of Trichophyton mentagrophytes which were isolated from three patients suffering from Tinea corporis (isolates No. 1, 5 and 6)and three patients suffering from Tinea faciei, Tinea manuum and Tinea capitis (isolates No. 2, 3 and 4 respectively).