Proton pump - key cell element in acid related digestive disorders

Proton pump - key cell element in acid related digestive disorders

Proton pump is the final step in gastric acid secretion, its physiopathological and pharmacological importance being undeniable in acid related digestive disorders. The knowledge of the intimate mechanisms of gastric secretion and the interaction of ATP-ase (adenosine triphosphatase) with various ce...

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Bibliographic Details
Published in:Human & veterinary medicine Vol. 3; no. 3; pp. 232 - 238
Main Authors: Săraci, George, Vesa, Ştefan C, Truţă, Anamaria
Format: Journal Article
Language:English
Published: Cluj-Napoca Bioflux SRL 01-12-2011
Subjects:
Adenosine
Adenosine triphosphatase
Adenosine triphosphate
Biochemistry
Gastric juice
Gastroenterology
Histamine
Proteins
Proton pump inhibitors
Protons
Secretion
Triphosphatase
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Summary:Proton pump is the final step in gastric acid secretion, its physiopathological and pharmacological importance being undeniable in acid related digestive disorders. The knowledge of the intimate mechanisms of gastric secretion and the interaction of ATP-ase (adenosine triphosphatase) with various cell proteins is essential in finding efficient and specific inhibitors in order to cure these diseases. The article proposes a synthesis of the most recent acquisitions in decoding gastric secretion mechanism, interaction between proton pump inhibitors (PPI) and the K/HATP-ase and in the main directions of studying the ATP-ase.
ISSN:2066-7655
2066-7663