Relative concentrations of 14C-DDT and of two polychlorinated biphenyls in the lipids of cod tissues after a single oral dose

• Published in: Archives of environmental contamination and toxicology Vol. 6; no. 4; p. 525
• Main Authors: Mitchell, A I, Plack, P A, Thomson, I M
• Format: Journal Article
• Language: English
• Published: United States 1977
• Subjects: Animals; DDT - pharmacokinetics; Fishes - metabolism; Lipid Metabolism; Polychlorinated Biphenyls - pharmacokinetics
• ISSN: 0090-4341

The concentrations of DDT and of two PCB's on the basis of total lipid in the tissues of COD killed from 2 hr to 14 days after a single oral dose are examined. Experimental methods and materials used are described. The absolute concentrations of DDT on a total lipid basis varied from fish to fish and from tissue to tissue, but the values for liver were highest for most of the fish. When the relative concentrations for each fish were calculated from values of Mgg ddt/g total lipid, similar values were obtained for the same tissues of different fish killed from one to 14 days after receiving the dose, indicating a rapid achievement of the equilibrium state. With the small number of fish used to determine the distribution of two PCB's, the results indicate a similar rapid distribution of the PCB's, but the relative concentrations in the lipids of the tissues were generally different from those obtained with DDT.