Synthesis, antimicrobial, and release behaviors of tetracycline hydrochloride loaded poly (VInyl alcohol)/chitosan/ZrO sub(2) nanofibers

• Published in: Journal of applied polymer science Vol. 132; no. 36; p. np
• Main Authors: Wang, Hualin, Chu, Chengjiang, Hao, Lilan, She, Yi, Li, Yanan, Zhai, Linfeng, Jiang, Shaotong
• Format: Journal Article
• Language: English
• Published: 01-09-2015
• Subjects: Beads; Chitosan; Drugs; Nanofibers; Polyvinyl alcohols; Staphylococcus aureus; Tetracyclines; Zirconium; Zirconium dioxide
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.42506

Tetracycline hydrochloride loaded poly (vinyl alcohol)/chitosan/ZrO sub(2) (Tet-PVA/CS/ZrO sub(2)) hybrid nanofibers were fabricated via electrospinning technique. The representative weight ratio of PVA/CS at 3 : 1 was chosen to fabricate drug carrier PVA/CS/ZrO sub(2) nanofibers. The drug carrier showed a decrease in average diameter with the increase of ZrO sub(2) content at given conditions, and the nanofibers were uneven and interspersed with spindle-shape beads with ZrO sub(2) content at 60 wt % and above. The networks linked by hydrogen and Zr-O-C bonds among PVA, CS, and ZrO sub(2) units resulted in the improving of thermal stability and decreasing of crystallinity of the polymeric matrix. Moreover, the incorporation of ZrO sub(2) endowed the fibers with ultraviolet shielding effect ranged from 200 to 400 nm. The Tet loading dosage had no obvious effect on the morphology and size of the medicated nanofibers at Tet content below 8 wt %, but interspersed with spindle-shaped beads when Tet content increased to 10 wt %. The Tet-PVA/CS/ZrO sub(2)) nanofibers showed well controlled release and better antimicrobial activity against Staphylococcus aureus, and the Tet release from the medicated nanofibers could be described by Fickian diffusion model for M sub(t) /M sub([infin])< 0.6. These medicated nanofibers may have potential as a suitable material in drug delivery and wound dressing. J. Appl. Polym. Sci. 2015, 132, 42506.