Concurrent IMRT Hyperfraction Radiochemotherapy Combined with Adjuvant Chemotherapy on Elderly Patients with Locally Advanced Esophageal Cancer

• Published in: Zhongliu fangzhi yanjiu Vol. 42; no. 8
• Main Authors: Luo, Yunxiu, He, Anbing, Long, Zhixiong, Yuan, Xi, Wan, Huan, Lang, Jinyi
• Format: Journal Article
• Language: Chinese
• Published: 01-01-2015
• ISSN: 1000-8578

Objective To observe the short-term eff icacy of concurrent IMRT hyperf raction radiochemotherapy combined with adjuvant chemotherapy on elderly patients with locally advanced esophageal cancer. Methods We retrospectively analyzed 52 elderly patients with locally advanced esophageal cancer. Thirty patients were grouped in observation group who were treated with concurrent hyperfraction IMRT(64.4-75.9Gy/56-66 F, 1.15Gy/F, Bid, 5F/W) and concurrent chemotherapy Nedaplatin(25-30mg/m2/W), following 4-6 cycles of adjuvant chemotherapy with capecitabine(2 000-2 500mg/m2). Other 22 patients whose radiotherapy program was 52-60Gy/26-30 F, 2Gy/F, Qd, 5F/W were divided into control group, and remaining treatment was same as observation group. Results In the observation group, the swallow obstruction of 28 patients were alleviated in one month after concurrent radiochemotherapy; the median survival time was 29 months; the 1-, 2- and 3-year survival rates were 87%, 66% and 25%, respectively. In the control group, the swa