Inflammageing in patients with idiopathic pulmonary fibrosis (IPF)

• Published in: Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) Vol. 71; no. 1; p. 72
• Main Authors: Rodríguez-Rodríguez, Ivon, Mesa-Gallo, Brayan Leonardo, Rico-Puentes, Yubely, González, Mauricio, Parra-López, Carlos Alberto
• Format: Journal Article
• Language: Spanish
• Published: Mexico 01-02-2024
• Subjects: Aged; Cytokines - blood; Female; Humans; Idiopathic Pulmonary Fibrosis - etiology; Inflammation; Male; Middle Aged; Aging; Inflammaging; Inflammatory cytokines; Idiopathic pulmonary fibrosis
• ISSN: 2448-9190
• DOI: 10.29262/ram.v71i1.1350

We took Peripheral blood samples from adult patients over 60 years of age with a confirmed diagnosis of IPF through biopsy or clinical criteria. Plasma separation was performed, and proinflammatory cytokines were measured using CBA. This study received approval from the ethics and research committee of the Colombian Pulmonological Foundation.
Patients with IPF exhibited an increase in cytokines such as IL-4, INFy, and IL-6 compared to healthy older adults.
Inflammatory disease has been associated with the development and coexistence of multiple chronic non-communicable diseases that have a higher incidence after 65 years of age. The involvement of adaptive immunity in the pathogenesis of IPF has been described as an imbalance in the Th1/Th2 lymphocyte response. Further studies are required to identify additional markers of immunosenescence that correlate with IPF.