DYNAMICS OF METABOLIC CHARACTERISTICS, MARKERS OF OXIDATIVE STRESS AND VASCULAR WALL DAMAGE DURING TREATMENT OF OBESE PRE-DIABETIC PATIENTS

We studied lipid and carbohydrate metabolism, markers of oxidative stress (plasma malonic dialdehyde and dienoic conjugates) and vascular wall damage (CRP microalbuminuria, blood desquamated endotheliocytes) before and after 12 week treatment of obese pre-diabetic patients. The study showed positive...

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Bibliographic Details
Published in:	Klinicheskaia meditsina Vol. 94; no. 3; p. 221
Main Authors:	Romanenko, L A, Polyatykina T S, Mavrycheva, N V, Budnikova, N V, Grinshtein, V B
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2016
Subjects:	Adult Albuminuria - metabolism Antioxidants - therapeutic use Biomarkers - metabolism Carbohydrate Metabolism - drug effects Combined Modality Therapy - methods Diet Therapy - methods Disease Management Endothelial Cells - pathology Female Humans Lipid Metabolism - drug effects Male Malondialdehyde - blood Middle Aged Motor Activity Obesity - diagnosis Obesity - metabolism Obesity - therapy Oxidative Stress - drug effects Prediabetic State - diagnosis Prediabetic State - metabolism Prediabetic State - therapy Statistics as Topic Treatment Outcome
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Summary:	We studied lipid and carbohydrate metabolism, markers of oxidative stress (plasma malonic dialdehyde and dienoic conjugates) and vascular wall damage (CRP microalbuminuria, blood desquamated endotheliocytes) before and after 12 week treatment of obese pre-diabetic patients. The study showed positive dynamics of the above metabolic parameters with normalization of carbohydrate metabolism in 60% of the patients and angioprotective effect of prescribed therapy. The proposed treatment can be used to prevent diabetes mellitus.
ISSN:	0023-2149