Ultrastructural changes in endothelial cells of blood capillaries of the Walker 256 carcinosarcoma while treated with melatonin

In Wistar rats with transplanted Walker 256 carcinosarcoma a use of melatonin as monoagent causes changes in intracellular organization of endothelial cells: reduced volume density of mitochondria, granular cytoplasmic network, micropinocytic vesicles, reduced the number density of free and attached...

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Bibliographic Details
Published in:	Voprosy onkologij Vol. 60; no. 2; p. 80
Main Authors:	Ovsianko, E V, Pustovetova, M G, Samsonova, E N, Ovsianko, Ia U, Fedina, R G, Kulishenko, A O, Vinogradov, A S
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 2014
Subjects:	Animals Antineoplastic Agents - administration & dosage Antineoplastic Agents - pharmacology Apoptosis - drug effects Capillaries - pathology Carcinoma 256, Walker - pathology Carcinoma 256, Walker - ultrastructure Cytoplasm - drug effects Endothelial Cells - ultrastructure Male Melatonin - administration & dosage Melatonin - pharmacology Mitochondria - drug effects Pinocytosis - drug effects Rats Ribosomes - drug effects
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Summary:	In Wistar rats with transplanted Walker 256 carcinosarcoma a use of melatonin as monoagent causes changes in intracellular organization of endothelial cells: reduced volume density of mitochondria, granular cytoplasmic network, micropinocytic vesicles, reduced the number density of free and attached ribosomes, which leads to increased apoptosis of tumor cells of Walker 256 carcinosarcoma.
ISSN:	0507-3758