Early interaction between tacrolimus and rifampin

Drug interactions are unavoidable and need to be proactively identified and managed, in particular, the inductive effect of rifampin on tacrolimus whose potency and duration data are limited. We report the case of a renal transplant patient who was prescribed tacrolimus with preserved tough blood le...

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Bibliographic Details
Published in:	Tunisie Medicale Vol. 97; no. 5; p. 722
Main Authors:	Charfi, Rim, Ben Sassi, Mouna, Gaïes, Emna, Bacha, Mongi, Jebabli, Nadia, El Jebari, Hanène, Daghfous, Riadh, Ben Abdallah, Taïeb, Trabelsi, Sameh
Format:	Journal Article
Language:	English
Published:	Tunisia 01-05-2019
Subjects:	Adult Antibiotics, Antitubercular - pharmacology Antibiotics, Antitubercular - therapeutic use Drug Interactions Humans Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Kidney Transplantation Male Rifampin - pharmacology Rifampin - therapeutic use Tacrolimus - pharmacology Tacrolimus - therapeutic use Time Factors
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Summary:	Drug interactions are unavoidable and need to be proactively identified and managed, in particular, the inductive effect of rifampin on tacrolimus whose potency and duration data are limited. We report the case of a renal transplant patient who was prescribed tacrolimus with preserved tough blood levels (C0) of 7.9 +/- 2 ng/mL. He presented ganglionic tuberculosis and started rifampin. One day later, C0 was 2.6 ng/mL with 5 mg/day. The serum creatinin was normal. Nine days later, C0 was 1.6 ng/mL with 7 mg/day. In this case-report, the tacrolimus-rifampin interaction occurred just one day after rifampin introduction necessitating early C0 monitoring.
ISSN:	0041-4131