Catecholamine content in the adrenal gland of rat offspring in the model of prenatal hyperhomocysteinemia

• Published in: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 100; no. 3; p. 360
• Main Authors: Miliutina, Iu P, Arutiunian, A V, Pustygina, A V, Shcherbitskaia, A D, Zalozniaia, I V, Zorina, I I
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-03-2014
• Subjects: Administration, Oral; Adrenal Glands - metabolism; Adrenal Glands - physiopathology; Animals; Animals, Newborn; Catecholamines - metabolism; Disease Models, Animal; Female; Hyperhomocysteinemia - etiology; Hyperhomocysteinemia - metabolism; Hyperhomocysteinemia - physiopathology; Methionine - administration & dosage; Methionine - adverse effects; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects - etiology; Prenatal Exposure Delayed Effects - metabolism; Prenatal Exposure Delayed Effects - physiopathology; Rats; Rats, Wistar; Tyrosine - analogs & derivatives; Tyrosine - blood
• ISSN: 0869-8139

Catecholamine content has been studied in the adrenal gland of rat females whose pregnant mothers were loaded daily with L-methionine administered per os during all the pregnancy period, on the first day of postnatal life, and in one and two months after birth. The animal model of hyperhomocysteinemia used in the experiment has been shown to result in the catecholamine content decreasing in the adrenal gland of both newly born rat offspring with high serum level of homocysteine and one-month old offspring with their homocysteine level decreased to the normal values. It was found that nitrotyrosine level increased significantly in the blood serum of the offspring aged one and two months. The data obtained may testify to oxidative stress development.