A Mendelian randomization study on the relationship between insomnia and osteoporosis

• Published in: Chung-hua nei kʿo tsa chih Vol. 63; no. 8; p. 776
• Main Authors: Liu, H Z, Fu, X M, Li, X J, Wang, Y H, Hu, X D, Xu, H J, Wang, A N, Lyu, Z H, Dong, S, Pei, Y
• Format: Journal Article
• Language: Chinese
• Published: China 01-08-2024
• Subjects: Genome-Wide Association Study; Humans; Mendelian Randomization Analysis; Osteoporosis - epidemiology; Osteoporosis - genetics; Polymorphism, Single Nucleotide; Risk Factors; Sleep Initiation and Maintenance Disorders - epidemiology; Sleep Initiation and Maintenance Disorders - genetics
• ISSN: 0578-1426
• DOI: 10.3760/cma.j.cn112138-20240207-00105

To explore the relationship between insomnia and osteoporosis.
Mendelian randomization (MR) analysis were used in this study. The single nucleotide polymorphisms (SNPs) related to insomnia from genome-wide association analysis research data were selected as the instrumental variables by using inverse variance weighted (IVW), MR-Egger regression, weighted median method, maximum likelihood, penalized weighted median estimator, and Mendelian randomization robust adjusted profile score (MR-RAPS) to determine the causal relationship between insomnia and osteoporosis. Odds ratio (
) and 95% confidence interval (
) values were used to evaluate the association between insomnia and osteoporosis. Cochran's
-test was used to detect heterogeneity of SNPs, MR-Egger regression was used to test for level pleiotropy, and the leave-one-out method was used to test sensitivity, MR pleiotropy residual sum and outlier (MR-PRESSO) method and radial MR were used to detect erroneous outliers.
The screening criteria were set based on