THE CHANGES IN FATTY ACIDS COMPOSITION IN THE AUDITORY CORTEX OF RATS AFTER A SINGLE AUDIOGENIC SEIZURE

• Published in: Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova Vol. 101; no. 9; p. 999
• Main Authors: Kulagina, T P, Aripovsky, A V, Savina, T A, Shchipakina, T G, Godukhin, O V
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01-09-2015
• Subjects: Animals; Auditory Cortex - chemistry; Auditory Cortex - metabolism; Auditory Cortex - physiopathology; Epilepsy, Reflex - metabolism; Epilepsy, Reflex - physiopathology; Fatty Acids - analysis; Fatty Acids - metabolism; Fatty Acids, Monounsaturated - analysis; Fatty Acids, Monounsaturated - metabolism; Lipid Metabolism; Male; Oxidation-Reduction; Rats; Rats, Inbred Strains; Rats, Wistar; Seizures - metabolism; Seizures - physiopathology; Species Specificity; Time Factors
• ISSN: 0869-8139

We found small but statistically significant increase in the number of stable to peroxide oxidation saturated and monounsaturated fatty acids in the auditory cortex of KM rats in comparison with control Wistar ones. The levels of fatty acids in the cells of the auditory cortex of KM rats were studied at different times (1 h, 1 day, 3 days and 14 days) after a single audiogenic seizure. The changes in fatty acids composition in auditory cortex of KM rats were found already in time point 1 h after convulsion, the maximal decrease of fatty acids levels was observed at 3 days after convulsion. These data suggest that the fatty acids pool in this time was depleted. Finally, we found the recovery of the better part of fatty acids in the auditory cortex of KM rats to 14 day after convulsion. These results can be used for development of new approaches to eliminate brain damage after seizures.