Current progress on trained immunity-based vaccines

Trained immunity-based vaccines (TIbV) is an emerging vaccine strategy in the field of vaccine research, referring to vaccines designed based on the principles of trained immunity (TI). TI involves the enhanced immune response of innate immune cells upon re-stimulation after being trained. TIbV, bui...

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Bibliographic Details
Published in:	Zhōnghuá yùfáng-yīxué zázhì Vol. 58; no. 10; p. 1598
Main Authors:	Xiang, C Y, Wang, N, Shi, Y
Format:	Journal Article
Language:	Chinese
Published:	China 06-10-2024
Subjects:	Humans Immunity, Innate Immunologic Memory Trained Immunity Vaccine Development Vaccines - immunology
Online Access:	Get more information
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Summary:	Trained immunity-based vaccines (TIbV) is an emerging vaccine strategy in the field of vaccine research, referring to vaccines designed based on the principles of trained immunity (TI). TI involves the enhanced immune response of innate immune cells upon re-stimulation after being trained. TIbV, built on the concept of TI, aims to enhance resistance to various infectious pathogens by training the host's innate immune system to acquire natural immune memory. This approach is designed to bolster immunity against a wide range of infectious agents, including those not covered by conventional vaccines. This article reviews the concepts, mechanisms, application areas, and future prospects of TIbV, intending to offer a new perspective for vaccine development and design.
ISSN:	0253-9624
DOI:	10.3760/cma.j.cn112150-20231121-00360