Longitudinal changes in 18 F-THK5351 positron emission tomography in corticobasal syndrome

• Published in: European journal of neurology Vol. 26; no. 9; pp. 1205 - 1211
• Main Authors: Ezura, M, Kikuchi, A, Ishiki, A, Okamura, N, Hasegawa, T, Harada, R, Watanuki, S, Funaki, Y, Hiraoka, K, Baba, T, Sugeno, N, Oshima, R, Yoshida, S, Kobayashi, J, Kobayashi, M, Tano, O, Nakashima, I, Mugikura, S, Iwata, R, Taki, Y, Furukawa, K, Arai, H, Furumoto, S, Tashiro, M, Yanai, K, Kudo, Y, Takeda, A, Aoki, M
• Format: Journal Article
• Language: English
• Published: England 01-09-2019
• Subjects: longitudinal change; corticobasal syndrome; monoamine oxidase B; tau deposits; PET; 18F-THK5351
• ISSN: 1468-1331
• DOI: 10.1111/ene.13966

Corticobasal syndrome (CBS) is pathologically characterized by tau deposits in neuronal and glial cells and by reactive astrogliosis. In several neurodegenerative disorders,
F-THK5351 has been observed to bind to reactive astrocytes expressing monoamine oxidase B. In this study, the aim was to investigate the progression of disease-related pathology in the brains of patients with CBS using positron emission tomography with
F-THK5351.
Baseline and 1-year follow-up imaging were acquired using magnetic resonance imaging and positron emission tomography with
F-THK5351 in 10 subjects: five patients with CBS and five age-matched normal controls (NCs).
The 1-year follow-up scan images revealed that
F-THK5351 retention had significantly increased in the superior parietal gyrus of the patients with CBS compared with the NCs. The median increases in
F-THK5351 accumulation in the patients with CBS were 6.53% in the superior parietal gyrus, 4.34% in the precentral gyrus and 4.33% in the postcentral gyrus. In contrast, there was no significant increase in the regional
F-THK5351 retention in the NCs.
Longitudinal increases in
F-THK5351 binding can be detected over a short interval in the cortical sites of patients with CBS. A monoamine oxidase B binding radiotracer could be useful in monitoring the progression of astrogliosis in CBS.