Phenylpropanoid glycosides from Sophorae Tonkinensis Radix et Rhizoma

Three phenylpropanoid glycosides were purified by extensive chromatographic techniques including column chromatography over microporous resin, MCI, diol, sephadex LH-20, reverse phase C_(18) from water-extracts of Sophorae Tonkinensis Radix et Rhizoma. Their planar structures were elucidated by comb...

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Published in:Zhongguo zhongyao zazhi Vol. 45; no. 22; p. 5525
Main Authors: Sheng-Li, Yang, Hao-Ke, H E, Meng-Yin, Tian, Xin, L I, Su-Juan, Wang
Format: Journal Article
Language:Chinese
Published: China 01-11-2020
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Abstract Three phenylpropanoid glycosides were purified by extensive chromatographic techniques including column chromatography over microporous resin, MCI, diol, sephadex LH-20, reverse phase C_(18) from water-extracts of Sophorae Tonkinensis Radix et Rhizoma. Their planar structures were elucidated by combination of various spectroscopic method, such as IR, UV, MS, and NMR. The absolute configuration of aglycone was determined by quantum chemical calculations. Their structures were elucidated as(8R)-3-(4-hydroxyphenyl)-1-propanol-2-O-β-D-glucopyranoside(1), kalopanaxin D(2),(E)-4-hydroxycinnamyl alcohol 4-O-[2'-O-β-D-apiofuranosyl(1″→2')]-β-D-glucopyranoside(3). Compound 1 was undescribed previously. Compounds 2 and 3 were firstly isolated from Sophora genus.
AbstractList Three phenylpropanoid glycosides were purified by extensive chromatographic techniques including column chromatography over microporous resin, MCI, diol, sephadex LH-20, reverse phase C_(18) from water-extracts of Sophorae Tonkinensis Radix et Rhizoma. Their planar structures were elucidated by combination of various spectroscopic method, such as IR, UV, MS, and NMR. The absolute configuration of aglycone was determined by quantum chemical calculations. Their structures were elucidated as(8R)-3-(4-hydroxyphenyl)-1-propanol-2-O-β-D-glucopyranoside(1), kalopanaxin D(2),(E)-4-hydroxycinnamyl alcohol 4-O-[2'-O-β-D-apiofuranosyl(1″→2')]-β-D-glucopyranoside(3). Compound 1 was undescribed previously. Compounds 2 and 3 were firstly isolated from Sophora genus.
Author Xin, L I
Su-Juan, Wang
Meng-Yin, Tian
Sheng-Li, Yang
Hao-Ke, H E
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  organization: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100050, China
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Sophorae Tonkinensis Radix et Rhizoma
phenylpropanoids
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Snippet Three phenylpropanoid glycosides were purified by extensive chromatographic techniques including column chromatography over microporous resin, MCI, diol,...
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SubjectTerms Drugs, Chinese Herbal
Ethanol
Glycosides
Rhizome
Sophora
Title Phenylpropanoid glycosides from Sophorae Tonkinensis Radix et Rhizoma
URI https://www.ncbi.nlm.nih.gov/pubmed/33350215
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