Phenylpropanoid glycosides from Sophorae Tonkinensis Radix et Rhizoma

• Published in: Zhongguo zhongyao zazhi Vol. 45; no. 22; p. 5525
• Main Authors: Sheng-Li, Yang, Hao-Ke, H E, Meng-Yin, Tian, Xin, L I, Su-Juan, Wang
• Format: Journal Article
• Language: Chinese
• Published: China 01-11-2020
• Subjects: Drugs, Chinese Herbal; Ethanol; Glycosides; Rhizome; Sophora; constituents; Sophorae Tonkinensis Radix et Rhizoma; phenylpropanoids
• ISSN: 1001-5302
• DOI: 10.19540/j.cnki.cjcmm.20200604.201

Three phenylpropanoid glycosides were purified by extensive chromatographic techniques including column chromatography over microporous resin, MCI, diol, sephadex LH-20, reverse phase C_(18) from water-extracts of Sophorae Tonkinensis Radix et Rhizoma. Their planar structures were elucidated by combination of various spectroscopic method, such as IR, UV, MS, and NMR. The absolute configuration of aglycone was determined by quantum chemical calculations. Their structures were elucidated as(8R)-3-(4-hydroxyphenyl)-1-propanol-2-O-β-D-glucopyranoside(1), kalopanaxin D(2),(E)-4-hydroxycinnamyl alcohol 4-O-[2'-O-β-D-apiofuranosyl(1″→2')]-β-D-glucopyranoside(3). Compound 1 was undescribed previously. Compounds 2 and 3 were firstly isolated from Sophora genus.